"Pentose-phosphate shunt, non-oxidative branch"

Across TCGA cell cohorts, RNA activity of the "Pentose-phosphate shunt, non-oxidative branch" pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TALDO1, SSR4, and RASSF7, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Pentose-phosphate shunt, non-oxidative branch" activity versus TALDO1 in STOMACH (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TALDO1 →	+0.885	+0.191	<.001	<.001	3	10
BONE	SSR4 →	+1.011	+0.231	<.001	.001	3	5
BREAST	RASSF7 →	+0.871	+0.116	<.001	.008	3	5
LUNG_NSCLC_LUAD	MACF1 →	-1.392	-0.149	.004	.003	3	5
SKIN	LAMP2 →	+1.199	+0.167	<.001	<.001	3	4
LUNG_SCLC	DHFR2 →	-0.756	-0.112	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009052 vs TALDO1 — STOMACH

Explore this scatter interactively →