Pyrimidine-containing compound salvage

Across TCGA patient cohorts, RNA activity of the Pyrimidine-containing compound salvage pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDA, MYO1E, and KAT7, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine-containing compound salvage activity versus CDA in GBM (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CDA →	+1.002	+0.047	<.001	.001	3	9
GBM	MYO1E →	+0.428	+0.068	<.001	<.001	3	8
OV	KAT7 →	-0.220	-0.051	.005	.004	2	8
GBM	PLAU →	+0.897	+0.076	<.001	<.001	3	7
LUAD	PLEC_S1570 →	+1.059	+0.061	.003	.002	3	7
LUAD	PLEC_S1721 →	+1.059	+0.061	.003	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008655 vs CDA — GBM

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