Pyrimidine-containing compound salvage

Across TCGA patient cohorts, RNA activity of the Pyrimidine-containing compound salvage pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UPP1, RRM2, and SGO1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine-containing compound salvage activity versus UPP1 in GBM (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UPP1 →	+0.875	+0.152	<.001	.005	3	5
LSCC	RRM2 →	+0.740	+0.191	.001	.002	3	5
LUAD	SGO1 →	+0.354	+0.129	.004	.001	3	5
COAD	NRBP1 →	+0.304	+0.618	<.001	.002	3	4
COAD	A4GNT →	+0.133	+0.970	<.001	<.001	3	4
LUAD	ZBED2 →	+0.733	+0.151	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008655 vs UPP1 — GBM

Explore this scatter interactively →