Pyrimidine-containing compound salvage

Across TCGA patient cohorts, RNA activity of the Pyrimidine-containing compound salvage pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UCKL1_S56, CAAP1_S203, and UCK2_S254, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine-containing compound salvage activity versus UCKL1_S56 in OV (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	UCKL1_S56 →	+0.812	+0.275	<.001	<.001	3	6
OV	CAAP1_S203 →	+1.041	+0.245	<.001	<.001	3	5
OV	UCK2_S254 →	+2.302	+0.389	<.001	<.001	3	5
OV	SERBP1_S197 →	+0.550	+0.294	.001	<.001	3	4
UCEC	UCKL1_S16 →	+0.386	+0.190	<.001	.002	3	3
OV	UHRF1BP1L_S989 →	-2.017	-0.352	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008655 vs UCKL1_S56 — OV

Explore this scatter interactively →