Pyrimidine-containing compound salvage

Across TCGA cell cohorts, RNA activity of the Pyrimidine-containing compound salvage pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP1A3, CAP1, and TRIP12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP1A3 grouped by Pyrimidine-containing compound salvage-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ATP1A3 →	-1.548	-1.183	.003	<.001	3	4
SKIN	CAP1 →	-0.568	-0.964	.001	.006	3	4
LUNG_SCLC	TRIP12 →	-0.852	-1.389	.004	.008	3	4
LUNG_NSCLC_LUAD	LAYN →	-1.847	-0.638	.001	.002	3	4
LUNG_NSCLC_LUSC	L3MBTL3 →	+1.257	+0.571	.002	.001	3	4
LIVER	PPM1H →	+1.585	+0.927	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP1A3 by Pyrimidine-containing compound salvage activity — PANCREAS

Explore this box plot interactively →