Pyrimidine-containing compound salvage

Across TCGA cell cohorts, RNA activity of the Pyrimidine-containing compound salvage pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAICS, ARHGEF37, and SCML2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine-containing compound salvage activity versus PAICS in BLOOD_Myeloma (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PAICS →	+0.828	+1.685	.004	<.001	3	5
BREAST	ARHGEF37 →	-1.417	-0.928	.002	.005	3	5
LUNG_SCLC	SCML2 →	+1.451	+1.266	.007	.002	3	4
LUNG_SCLC	DUSP22 →	-1.407	-0.816	<.001	.001	3	4
LUNG_SCLC	TMEM134 →	-1.314	-0.921	.005	.005	3	4
CNS	H2BC15 →	-0.940	-0.918	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008655 vs PAICS — BLOOD_Myeloma

Explore this scatter interactively →