Phospholipid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Phospholipid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, SEPTIN4, and TNS2_S102, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phospholipid biosynthetic process activity versus RPL5 in CCRCC (Pearson r = -0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RPL5 →	-0.263	-0.034	<.001	<.001	3	8
GBM	SEPTIN4 →	+0.608	+0.025	<.001	<.001	3	8
BRCA	TNS2_S102 →	+0.745	+0.024	<.001	<.001	3	8
CCRCC	PLAC9 →	+0.648	+0.030	<.001	<.001	3	8
CCRCC	PPP1R12B →	+0.721	+0.035	<.001	<.001	3	8
GBM	SERBP1 →	-0.185	-0.022	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008654 vs RPL5 — CCRCC

Explore this scatter interactively →