Phospholipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Phospholipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERP44, RBM5, and BCAR3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ERP44 grouped by Phospholipid biosynthetic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ERP44 →	-0.414	-0.548	.004	.008	3	4
LIVER	RBM5 →	-0.729	-0.259	<.001	<.001	3	4
LIVER	BCAR3 →	-2.145	-0.225	.008	.004	3	3
LUNG_NSCLC_LUSC	PELI1 →	+1.829	+1.635	.001	<.001	3	3
BLOOD_Leukemia	INHBA →	-0.470	-0.602	.004	.003	3	3
BLOOD_Leukemia	HELB →	-0.643	-0.544	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ERP44 by Phospholipid biosynthetic process activity — BLOOD_Leukemia

Explore this box plot interactively →