Carbohydrate transport

Across TCGA patient cohorts, RNA activity of the Carbohydrate transport pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF180, RASSF8-AS1, and ABCB4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate transport activity versus RNF180 in HNSC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNF180 →	+0.450	+0.564	.003	<.001	3	4
HNSC	RASSF8-AS1 →	+0.593	+0.801	<.001	<.001	3	4
HNSC	ABCB4 →	+0.450	+0.553	<.001	<.001	3	4
HNSC	JAM3 →	+0.503	+0.608	.009	.006	3	3
CCRCC	NDNF →	+1.597	+0.466	.003	.005	3	3
PDAC	PTPRM →	+0.380	+0.433	.004	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008643 vs RNF180 — HNSC

Explore this scatter interactively →