Carbohydrate transport

Across TCGA cell cohorts, RNA activity of the Carbohydrate transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN2AIPNL, MRPL10, and RNF25, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDKN2AIPNL grouped by Carbohydrate transport-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CDKN2AIPNL →	+0.750	+0.878	<.001	<.001	3	4
BLOOD_Lymphoma	MRPL10 →	+0.716	+1.925	<.001	<.001	3	4
BLOOD_Lymphoma	RNF25 →	+0.959	+1.925	.004	<.001	3	4
OESOPHAGUS	SLC7A8 →	+4.256	+1.448	.008	.002	3	4
SOFT_TISSUE	METTL2B →	+0.628	+1.027	.001	.005	3	3
BLOOD_Leukemia	MAN1A1 →	+2.385	+0.943	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDKN2AIPNL by Carbohydrate transport activity — BREAST

Explore this box plot interactively →