Attachment of spindle microtubules to kinetochore

Across TCGA patient cohorts, RNA activity of the Attachment of spindle microtubules to kinetochore pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ORC6, CENPI, and RAD51AP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Attachment of spindle microtubules to kinetochore activity versus ORC6 in BRCA (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ORC6 →	+1.238	+1.205	<.001	<.001	3	7
GBM	CENPI →	+0.776	+0.940	<.001	<.001	3	7
BRCA	RAD51AP1 →	+0.914	+0.748	<.001	<.001	3	7
BRCA	TTK →	+1.009	+1.007	<.001	<.001	3	7
GBM	CCDC150 →	+0.594	+0.986	<.001	<.001	3	7
BRCA	MTFR2 →	+0.808	+1.060	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008608 vs ORC6 — BRCA

Explore this scatter interactively →