Attachment of spindle microtubules to kinetochore

Across TCGA cell cohorts, RNA activity of the Attachment of spindle microtubules to kinetochore pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYB561A3, NAA20, and TMEM265, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYB561A3 grouped by Attachment of spindle microtubules to kinetochore-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CYB561A3 →	-0.976	-0.455	<.001	.003	3	4
UPPER_AERODIGESTIVE_TRACT	NAA20 →	+0.643	+0.311	.002	.001	3	4
OVARY	TMEM265 →	+2.170	+0.286	<.001	.003	3	4
LIVER	ASAP3 →	-1.713	-0.459	<.001	<.001	3	4
OVARY	PRCC →	-0.673	-0.235	<.001	<.001	3	4
LUNG_NSCLC_LUAD	PPP1R15B →	-0.317	-0.147	.005	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYB561A3 by Attachment of spindle microtubules to kinetochore activity — BLOOD_Myeloma

Explore this box plot interactively →