Attachment of spindle microtubules to kinetochore

Across TCGA cell cohorts, RNA activity of the Attachment of spindle microtubules to kinetochore pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRFN1, NFRKB, and SERPINB8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Attachment of spindle microtubules to kinetochore activity versus LRFN1 in SKIN (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LRFN1 →	+0.846	+0.954	<.001	<.001	3	5
SKIN	NFRKB →	+0.578	+0.881	.001	.004	3	5
BLOOD_Lymphoma	SERPINB8 →	-2.159	-0.485	.001	.008	3	4
BLOOD_Lymphoma	PXMP2 →	+0.949	+0.566	.003	.005	2	5
LIVER	MT1F →	-3.955	-1.078	.008	.004	3	4
LARGE_INTESTINE	RPRD1B →	+0.597	+0.805	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008608 vs LRFN1 — SKIN

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