Regulation of smoothened signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of smoothened signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FHL3, PDLIM4, and TAGLN, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of smoothened signaling pathway activity versus FHL3 in OV (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FHL3 →	+0.797	+0.058	<.001	<.001	3	9
COAD	PDLIM4 →	+0.602	+0.043	<.001	<.001	3	9
OV	TAGLN →	+1.263	+0.065	<.001	<.001	3	8
OV	THBS2 →	+1.442	+0.050	<.001	.001	3	8
CCRCC	THBS3 →	+0.668	+0.029	.005	.002	3	8
OV	TIMP2 →	+0.649	+0.061	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008589 vs FHL3 — OV

Explore this scatter interactively →