Regulation of smoothened signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of smoothened signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAV21, FZD2, and P2RY14, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of smoothened signaling pathway activity versus TRAV21 in HNSC (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRAV21 →	-0.719	-0.388	.007	<.001	3	3
UCEC	FZD2 →	+0.622	+0.385	.003	<.001	3	3
OV	P2RY14 →	-0.545	-0.611	<.001	<.001	3	3
OV	TRBV9 →	-0.917	-0.544	<.001	.007	3	3
OV	ARHGAP15 →	-0.512	-0.576	.004	<.001	3	3
PDAC	RNU6-310P →	-0.845	-0.305	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008589 vs TRAV21 — HNSC

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