Regulation of smoothened signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of smoothened signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KPNA3, GPR155, and MRPS28, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of smoothened signaling pathway activity versus KPNA3 in BLOOD_Myeloma (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	KPNA3 →	+0.631	+0.219	.004	.006	2	6
LUNG_NSCLC_LUAD	GPR155 →	+0.524	+0.095	.005	.009	3	4
OESOPHAGUS	MRPS28 →	-0.760	-0.184	.009	.004	3	4
BONE	CPT1C →	+2.266	+0.215	.007	.004	2	5
BLOOD_Lymphoma	DHRS13 →	-0.686	-0.137	.003	.003	3	4
PANCREAS	ZNF354B →	+0.868	+0.237	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008589 vs KPNA3 — BLOOD_Myeloma

Explore this scatter interactively →