Regulation of synaptic assembly at neuromuscular junction

Across TCGA patient cohorts, RNA activity of the Regulation of synaptic assembly at neuromuscular junction pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO, UBLCP1, and ECE1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synaptic assembly at neuromuscular junction activity versus SYNPO in LSCC (Pearson r = 0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SYNPO →	-0.277	-0.087	.003	.004	3	5
UCEC	UBLCP1 →	-0.344	-0.119	<.001	<.001	3	5
LSCC	ECE1 →	+0.824	+0.147	<.001	<.001	3	5
LSCC	HOOK1 →	+0.376	+0.085	<.001	<.001	3	5
CCRCC	PRKCZ →	+0.229	+0.082	.002	.001	3	5
UCEC	CHKA →	+0.348	+0.082	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008582 vs SYNPO — LSCC

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