Regulation of synaptic assembly at neuromuscular junction

Across TCGA patient cohorts, RNA activity of the Regulation of synaptic assembly at neuromuscular junction pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYCBP2-AS1, MST1P2, and KHDC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synaptic assembly at neuromuscular junction activity versus MYCBP2-AS1 in UCEC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYCBP2-AS1 →	+0.290	+0.649	.003	.004	3	5
CCRCC	MST1P2 →	-0.599	-0.645	<.001	<.001	3	4
OV	KHDC1 →	+0.529	+0.503	.003	.005	3	3
BRCA	ARHGAP12 →	-0.404	-0.694	.009	.003	3	3
LUAD	CLNK →	+0.441	+0.649	.002	.001	3	3
CCRCC	FKBP11 →	+0.563	+0.633	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008582 vs MYCBP2-AS1 — UCEC

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