Regulation of synaptic assembly at neuromuscular junction

Across TCGA cell cohorts, RNA activity of the Regulation of synaptic assembly at neuromuscular junction pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLPP, LAMC1, and TRMT112, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synaptic assembly at neuromuscular junction activity versus CLPP in BLOOD_Myeloma (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CLPP →	-0.681	-1.136	.009	.001	2	5
BLOOD_Leukemia	LAMC1 →	+2.158	+1.057	.002	<.001	3	4
CNS	TRMT112 →	-0.550	-0.652	.005	.004	3	4
LIVER	SMIM24 →	+2.965	+0.407	.001	.001	2	5
SKIN	GSR →	-0.656	-0.733	.002	.001	3	4
BLOOD_Lymphoma	PPID →	-1.261	-1.248	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008582 vs CLPP — BLOOD_Myeloma

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