Respiratory chain complex IV assembly

Across TCGA patient cohorts, RNA activity of the Respiratory chain complex IV assembly pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNKS1BP1_S1073, LSP1_S139, and TYMP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Respiratory chain complex IV assembly activity versus TNKS1BP1_S1073 in HNSC (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TNKS1BP1_S1073 →	-0.582	-0.046	<.001	.003	3	6
LSCC	LSP1_S139 →	-0.735	-0.032	<.001	.003	3	6
OV	TYMP →	-0.619	-0.024	<.001	<.001	3	6
PDAC	CKAP4_S26 →	-0.551	-0.028	<.001	.002	3	6
BRCA	NUP88 →	+0.157	+0.020	.001	.005	3	6
HNSC	SH3BGRL3 →	-0.387	-0.063	.005	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008535 vs TNKS1BP1_S1073 — HNSC

Explore this scatter interactively →