Asymmetric cell division

Across TCGA patient cohorts, RNA activity of the Asymmetric cell division pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC4, MCM4_S120, and UHRF1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Asymmetric cell division activity versus SMC4 in BRCA (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SMC4 →	+0.446	+0.037	<.001	.001	3	6
LUAD	MCM4_S120 →	+0.796	+0.044	.008	.008	2	7
BRCA	UHRF1 →	+0.613	+0.043	<.001	<.001	3	6
COAD	CDK1 →	+0.529	+0.032	<.001	.002	3	6
BRCA	TNS2_S120 →	-0.513	-0.033	<.001	.003	3	6
CCRCC	RRM2_S20 →	+0.947	+0.065	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008356 vs SMC4 — BRCA

Explore this scatter interactively →