Asymmetric cell division

Across TCGA patient cohorts, RNA activity of the Asymmetric cell division pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR1D, OR7E13P, and GMPR2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Asymmetric cell division activity versus POLR1D in LUAD (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	POLR1D →	+0.325	+0.387	<.001	.001	3	4
LUAD	OR7E13P →	-0.426	-0.277	.004	.002	3	4
CCRCC	GMPR2 →	-0.290	-0.536	<.001	.002	3	4
CCRCC	RPE →	+0.174	+0.515	.004	.003	3	4
PDAC	CEP290 →	+0.298	+0.548	.001	.008	3	4
CCRCC	MCUB →	+0.614	+0.731	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008356 vs POLR1D — LUAD

Explore this scatter interactively →