Asymmetric cell division

Across TCGA cell cohorts, RNA activity of the Asymmetric cell division pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRUB1, SCARB1, and NIBAN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Asymmetric cell division activity versus TRUB1 in LARGE_INTESTINE (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TRUB1 →	-0.769	-0.143	<.001	.005	3	5
SOFT_TISSUE	SCARB1 →	-1.866	-0.267	.005	.001	3	5
BLOOD_Leukemia	NIBAN2 →	+1.703	+0.142	<.001	.003	3	5
LUNG_NSCLC_LUAD	COPRS →	-0.512	-0.136	.007	.005	3	5
LUNG_NSCLC_LUAD	ABCG4 →	-0.323	-0.135	<.001	.005	3	5
BREAST	TTLL11 →	+0.699	+0.224	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008356 vs TRUB1 — LARGE_INTESTINE

Explore this scatter interactively →