Germ cell migration

Across TCGA patient cohorts, RNA activity of the Germ cell migration pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXADR, LEF1, and TRAF5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Germ cell migration activity versus CXADR in UCEC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CXADR →	+0.669	+0.384	.001	.009	2	5
BRCA	LEF1 →	-0.987	-0.460	<.001	<.001	3	4
GBM	TRAF5 →	-0.454	-0.284	<.001	<.001	3	4
GBM	MARVELD1 →	-0.406	-0.213	.005	.005	3	4
BRCA	GPR137B →	-0.487	-0.317	.001	.003	3	4
BRCA	RAB31 →	-0.560	-0.360	.009	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008354 vs CXADR — UCEC

Explore this scatter interactively →