Germ cell migration

Across TCGA cell cohorts, RNA activity of the Germ cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB10, ZNHIT1, and CD80, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB10 grouped by Germ cell migration-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RAB10 →	-0.196	-1.664	.009	<.001	3	3
LUNG_SCLC	ZNHIT1 →	+0.300	+0.288	<.001	<.001	3	3
LUNG_SCLC	CD80 →	-0.176	-0.240	.004	.001	3	3
KIDNEY	SUPT20H →	-0.235	-0.838	.002	.004	3	3
KIDNEY	ARL5B →	-0.298	-1.091	.007	.003	3	3
CNS	ZNF541 →	-0.218	-1.035	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB10 by Germ cell migration activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →