Glial cell migration

Across TCGA cell cohorts, RNA activity of the Glial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CISD3, ITGB1, and DHRS13, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glial cell migration activity versus CISD3 in STOMACH (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CISD3 →	-1.472	-0.580	<.001	<.001	3	6
BREAST	ITGB1 →	+1.785	+0.287	<.001	.009	3	6
LUNG_NSCLC_LUSC	DHRS13 →	-1.091	-0.449	.005	.006	3	6
BREAST	MARS2 →	-0.640	-0.272	<.001	<.001	3	6
LUNG_NSCLC_LUSC	C1orf43 →	-0.834	-0.501	.004	.001	3	6
PANCREAS	MRPS27 →	-1.011	-0.411	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008347 vs CISD3 — STOMACH

Explore this scatter interactively →