Histone mRNA metabolic process

Across TCGA patient cohorts, RNA activity of the Histone mRNA metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TAGLN2_S163, ADNP, and GATAD2B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Histone mRNA metabolic process activity versus TAGLN2_S163 in LUAD (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TAGLN2_S163 →	-0.583	-0.025	.001	.005	3	6
LSCC	ADNP →	+0.274	+0.031	.002	.004	3	6
LSCC	GATAD2B →	+0.292	+0.039	.003	.002	3	6
UCEC	SETDB1 →	+0.183	+0.040	.005	.004	3	5
LSCC	SF3B3 →	+0.196	+0.042	.003	<.001	2	6
LUAD	C2orf49 →	+0.244	+0.030	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008334 vs TAGLN2_S163 — LUAD

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