Endosome to lysosome transport

Across TCGA cell cohorts, RNA activity of the Endosome to lysosome transport pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VCP, TSG101, and WDR36, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VCP grouped by Endosome to lysosome transport-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	VCP →	-0.457	-0.251	.006	.003	1	8
LIVER	TSG101 →	-0.570	-0.461	.001	<.001	3	5
LIVER	WDR36 →	+0.546	+0.346	<.001	.002	3	4
LUNG_NSCLC_LUAD	SUSD3 →	+0.142	+0.185	<.001	.001	3	4
LUNG_SCLC	NIFK →	+0.396	+0.303	.002	.007	3	4
OESOPHAGUS	TNFRSF11A →	+0.190	+0.372	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VCP by Endosome to lysosome transport activity — PANCREAS

Explore this box plot interactively →