Endosome to lysosome transport

Across TCGA cell cohorts, RNA activity of the Endosome to lysosome transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB2A, LRP4, and ETS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB2A grouped by Endosome to lysosome transport-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RAB2A →	+0.729	+0.262	.007	.009	3	4
LUNG_NSCLC_LUSC	LRP4 →	-2.490	-0.306	.002	.001	3	4
LUNG_NSCLC_LUSC	ETS1 →	+3.198	+0.294	.005	.001	2	5
LUNG_NSCLC_LUSC	STAM →	+1.590	+0.327	<.001	.001	3	4
LUNG_NSCLC_LUSC	MUS81 →	+0.816	+0.243	.002	.002	3	4
LUNG_NSCLC_LUSC	GPX2 →	-7.093	-0.304	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB2A by Endosome to lysosome transport activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →