Associative learning

Across TCGA cell cohorts, RNA activity of the Associative learning pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GEM, ORAI2, and THNSL2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Associative learning activity versus GEM in OESOPHAGUS (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GEM →	-2.111	-0.242	.001	.001	2	7
BLOOD_Lymphoma	ORAI2 →	-2.623	-0.275	<.001	<.001	3	5
URINARY_TRACT	THNSL2 →	+2.534	+0.295	.001	.001	3	4
URINARY_TRACT	CDS1 →	+3.180	+0.334	<.001	.004	3	4
URINARY_TRACT	RNF223 →	+1.941	+0.202	.005	.001	3	4
URINARY_TRACT	TMEM265 →	+3.083	+0.185	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008306 vs GEM — OESOPHAGUS

Explore this scatter interactively →