Isoprenoid catabolic process

Across TCGA patient cohorts, RNA activity of the Isoprenoid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR1C3, AKR1B10, and SLC9A3R1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isoprenoid catabolic process activity versus AKR1C3 in LSCC (Pearson r = 0.78).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKR1C3 →	+2.016	+0.167	<.001	<.001	3	8
LSCC	AKR1B10 →	+2.788	+0.155	<.001	<.001	3	7
LSCC	SLC9A3R1 →	+0.561	+0.087	<.001	<.001	3	6
LSCC	TALDO1 →	+0.634	+0.135	<.001	<.001	3	6
LSCC	G6PD →	+0.979	+0.154	<.001	<.001	3	6
PDAC	FKBP10 →	-0.210	-0.059	.006	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008300 vs AKR1C3 — LSCC

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