Isoprenoid catabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Isoprenoid catabolic process pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 10 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Isoprenoid catabolic process pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and COAD, show the opposite pattern, with higher activity associated with better survival.

HNSC, KIRC, and ESCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.458	0.643	.001	64	view →
KIRC	DFS	Quartile	All	0.712	0.494	<.001	54	view →
ESCA	DFS	Median	II,III,IV	0.239	0.460	.001	51	view →
COAD	DFS	Quartile	All	0.787	0.590	.008	37	view →
SKCM	OS	Median	II,III,IV	0.269	0.502	<.001	31	view →
DLBC	DFS	Median	All	0.947	0.568	.008	13	view →
ACC	OS	Median	All	0.882	0.717	.016	11	view →
PAAD	DFS	Median	III,IV	0.370	0.853	.010	9	view →
THCA	OS	Tertile	All	0.958	1.000	.019	8	view →
READ	DFS	Quartile	All	0.835	0.450	.020	7	view →
CHOL	DFS	Tertile	II,III,IV	0.116	0.608	.033	6	view →
OV	DFS	Quartile	III,IV	0.247	0.161	.030	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0008300–HNSC (DFS)

Open the HNSC breakdown →