Isoprenoid catabolic process

Across TCGA patient cohorts, RNA activity of the Isoprenoid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1C3, AKR1B10, and UGT1A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isoprenoid catabolic process activity versus AKR1C3 in LSCC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKR1C3 →	+2.253	+0.423	<.001	<.001	3	6
LUAD	AKR1B10 →	+2.502	+0.337	<.001	<.001	3	5
LUAD	UGT1A1 →	+0.997	+0.387	<.001	.009	2	5
PDAC	MUC6 →	+2.109	+0.479	<.001	.003	3	4
LSCC	DNAJB3 →	+1.093	+0.347	.001	.006	3	4
LUAD	SRD5A3 →	+0.770	+0.404	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008300 vs AKR1C3 — LSCC

Explore this scatter interactively →