Isoprenoid catabolic process

Across TCGA cell cohorts, RNA activity of the Isoprenoid catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCDHA5, PRRG4, and ZNF638, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PCDHA5 grouped by Isoprenoid catabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PCDHA5 →	+0.260	+2.105	.003	.003	3	2
OESOPHAGUS	PRRG4 →	+0.190	+1.886	.001	.003	2	2
LUNG_NSCLC_LUAD	ZNF638 →	+0.190	+1.206	.002	.006	3	1
BREAST	CHD8 →	-0.415	-1.643	.008	.009	3	1
BREAST	XIAP →	+0.250	+2.111	.004	<.001	3	1
BREAST	RBM3 →	-0.136	-2.136	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PCDHA5 by Isoprenoid catabolic process activity — BREAST

Explore this box plot interactively →