Isoprenoid catabolic process

Across TCGA cell cohorts, RNA activity of the Isoprenoid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGD, TNFAIP1, and KLF7, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isoprenoid catabolic process activity versus PGD in LUNG_NSCLC_LUAD (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PGD →	+1.951	+1.497	.005	.006	3	3
LUNG_NSCLC_LUAD	TNFAIP1 →	-0.926	-1.251	.001	.001	3	2
LUNG_NSCLC_LUAD	KLF7 →	-0.980	-1.139	.005	.006	3	2
LUNG_NSCLC_LUAD	SLC25A23 →	-1.290	-1.092	.001	.009	3	2
LUNG_NSCLC_LUAD	CHSY1 →	-0.806	-1.170	.001	.004	3	2
LUNG_NSCLC_LUAD	BMP2K →	-0.851	-1.189	.008	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008300 vs PGD — LUNG_NSCLC_LUAD

Explore this scatter interactively →