Isoprenoid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Isoprenoid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MVD, IDI1, and MVK, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isoprenoid biosynthetic process activity versus MVD in BRCA (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MVD →	+0.391	+0.032	.002	.004	3	7
BRCA	IDI1 →	+0.460	+0.035	<.001	<.001	3	6
HNSC	MVK →	+0.350	+0.081	<.001	<.001	3	6
LSCC	DHRS3 →	+0.633	+0.055	<.001	<.001	3	5
BRCA	RDH10 →	+0.633	+0.033	<.001	<.001	3	5
LSCC	SMARCA2 →	-0.304	-0.044	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008299 vs MVD — BRCA

Explore this scatter interactively →