Isoprenoid biosynthetic process

Across TCGA pan-cancer cohorts, RNA activity of the Isoprenoid biosynthetic process pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 29 member genes.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher Isoprenoid biosynthetic process pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ESCA and READ, show the opposite pattern, with higher activity associated with better survival.

LIHC, UVM, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.597	0.749	<.001	65	view →
UVM	DFS	Tertile	All	0.543	1.000	.004	50	view →
KIRC	DFS	Quartile	All	0.575	0.714	.002	46	view →
BLCA	DFS	Median	All	0.457	0.573	.006	38	view →
LGG	DFS	Tertile	All	0.699	0.904	<.001	36	view →
CHOL	DFS	Tertile	II,III,IV	0.128	0.445	.021	27	view →
HNSC	DFS	Median	All	0.257	0.382	.012	26	view →
ESCA	OS	Tertile	III,IV	0.688	0.317	.009	21	view →
READ	DFS	Quartile	II,III,IV	0.845	0.311	.012	19	view →
UCEC	DFS	Quartile	All	0.580	0.776	.001	18	view →
ACC	DFS	Tertile	III,IV	0.525	0.222	.017	17	view →
MESO	OS	Median	All	0.282	0.458	.003	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0008299–LIHC (OS)

Open the LIHC breakdown →