Isoprenoid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Isoprenoid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RDH10, LINC01933, and LBP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isoprenoid biosynthetic process activity versus RDH10 in LSCC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RDH10 →	+0.581	+0.133	.004	.005	3	5
LUAD	LINC01933 →	-0.161	-0.183	.003	.002	3	4
UCEC	LBP →	+1.244	+0.143	.009	.003	3	4
LSCC	HMGCS1 →	+0.894	+0.280	<.001	<.001	3	4
HNSC	MVD →	+0.607	+0.194	.002	<.001	3	4
LSCC	UBE2V1P9 →	-0.036	-0.262	.009	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008299 vs RDH10 — LSCC

Explore this scatter interactively →