Isoprenoid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Isoprenoid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TDRKH, APOL6, and FGF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isoprenoid biosynthetic process activity versus TDRKH in SKIN (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TDRKH →	+0.873	+1.343	<.001	.001	3	6
BLOOD_Lymphoma	APOL6 →	-2.524	-0.960	<.001	.003	3	5
OVARY	FGF1 →	-1.091	-1.033	<.001	<.001	3	4
LUNG_NSCLC_LUAD	ACAT2 →	+1.299	+1.152	<.001	<.001	3	4
LIVER	TOMM5 →	+1.324	+0.510	.005	.003	3	4
BLOOD_Lymphoma	CSF1R →	-2.125	-0.678	.005	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008299 vs TDRKH — SKIN

Explore this scatter interactively →