Intracellular mRNA localization

Across TCGA patient cohorts, RNA activity of the Intracellular mRNA localization pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOS1, USP42, and XRN1, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular mRNA localization activity versus SOS1 in UVM (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	SOS1 →	+1.375	+0.053	<.001	<.001	3	33
KIRP	USP42 →	+0.761	+0.041	<.001	<.001	3	32
CHOL	XRN1 →	+1.611	+0.068	<.001	<.001	3	32
KIRP	PHC3 →	+0.911	+0.052	<.001	<.001	3	32
UVM	RB1CC1 →	+1.819	+0.056	<.001	<.001	3	32
UVM	STAU2 →	+1.259	+0.055	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008298 vs SOS1 — UVM

Explore this scatter interactively →