Intracellular mRNA localization

Across TCGA patient cohorts, RNA activity of the Intracellular mRNA localization pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BLNK, STAU2, and CASP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular mRNA localization activity versus BLNK in COAD (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	BLNK →	-0.510	-0.044	<.001	.008	3	7
LSCC	STAU2 →	+0.302	+0.063	.001	<.001	3	6
LSCC	CASP1 →	-0.233	-0.033	.001	.004	3	6
LSCC	CD48 →	-0.535	-0.058	<.001	<.001	3	6
PDAC	DEF6 →	-0.279	-0.059	<.001	<.001	3	6
LSCC	GPSM3 →	-0.336	-0.055	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008298 vs BLNK — COAD

Explore this scatter interactively →