Intracellular mRNA localization

Across TCGA patient cohorts, RNA activity of the Intracellular mRNA localization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POC1A, MELK, and AURKB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular mRNA localization activity versus POC1A in BRCA (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	POC1A →	+0.547	+0.329	<.001	.002	3	4
BRCA	MELK →	+0.716	+0.343	.006	.005	3	4
UCEC	AURKB →	+0.888	+0.176	<.001	.002	3	4
BRCA	FANCA →	+0.554	+0.255	.001	.004	3	4
BRCA	NPM1P9 →	+0.315	+0.226	.009	.009	3	4
HNSC	GINS4 →	+0.620	+0.182	.007	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008298 vs POC1A — BRCA

Explore this scatter interactively →