Intracellular mRNA localization

Across TCGA cell cohorts, RNA activity of the Intracellular mRNA localization pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL4A, VOPP1, and DPH5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARL4A grouped by Intracellular mRNA localization-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ARL4A →	-0.930	-1.219	.008	.003	3	5
BLOOD_Leukemia	VOPP1 →	-1.697	-1.175	.004	.002	3	4
LUNG_NSCLC_LUSC	DPH5 →	+0.803	+1.875	.003	<.001	3	4
OESOPHAGUS	SH3BP5 →	-1.260	-1.429	.006	.004	3	4
LUNG_NSCLC_LUSC	GALNT11 →	-1.117	-1.700	.006	.007	2	5
OESOPHAGUS	ZNRF2 →	-0.799	-1.290	.009	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARL4A by Intracellular mRNA localization activity — CNS

Explore this box plot interactively →