Intracellular mRNA localization

Across TCGA cell cohorts, RNA activity of the Intracellular mRNA localization pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BICD1, YEATS2, and SPECC1L, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular mRNA localization activity versus BICD1 in KIDNEY (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	BICD1 →	+1.182	+0.100	.007	.002	3	13
LUNG_NSCLC_LUSC	YEATS2 →	+1.208	+0.149	.002	<.001	3	11
LARGE_INTESTINE	SPECC1L →	+0.797	+0.097	.001	.001	3	10
BLOOD_Lymphoma	HDGFL2 →	+0.997	+0.080	<.001	<.001	3	10
BLOOD_Lymphoma	MBD3 →	+1.075	+0.099	<.001	<.001	3	10
STOMACH	RAPGEF1 →	+0.897	+0.122	.002	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008298 vs BICD1 — KIDNEY

Explore this scatter interactively →