Insulin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Insulin receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANXA6, PRELP, and RPL5, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Insulin receptor signaling pathway activity versus ANXA6 in BRCA (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ANXA6 →	+0.487	+0.037	<.001	<.001	3	9
BRCA	PRELP →	+0.877	+0.035	<.001	<.001	3	9
BRCA	RPL5 →	-0.245	-0.037	<.001	<.001	3	8
GBM	CLPX →	-0.261	-0.042	<.001	<.001	3	8
BRCA	SORBS1 →	+0.722	+0.039	<.001	<.001	3	8
BRCA	SPTBN1_S257 →	+0.667	+0.038	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008286 vs ANXA6 — BRCA

Explore this scatter interactively →