Insulin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Insulin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BVES, FASTKD1, and RN7SKP78, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Insulin receptor signaling pathway activity versus BVES in OV (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	BVES →	+1.619	+0.258	.005	.007	3	2
OV	FASTKD1 →	-0.699	-0.257	.004	.007	3	2
COAD	RN7SKP78 →	-0.291	-0.924	.001	.001	3	2
BRCA	MMP15 →	-1.916	-0.188	<.001	.005	3	1
BRCA	FAM168B →	+0.934	+0.286	.009	.007	3	1
BRCA	BACH1 →	-1.105	-0.188	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008286 vs BVES — OV

Explore this scatter interactively →