Insulin receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Insulin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC171, CIT, and HSPA1L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC171 grouped by Insulin receptor signaling pathway-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CCDC171 →	-1.440	-1.859	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	CIT →	-1.475	-0.257	.004	.002	3	4
KIDNEY	HSPA1L →	+0.345	+0.684	.002	.009	3	4
LARGE_INTESTINE	WDR43 →	-0.425	-0.528	.002	.003	3	4
STOMACH	HDAC1 →	-0.700	-0.222	.004	.001	3	4
STOMACH	CENATAC →	-1.052	-0.265	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC171 by Insulin receptor signaling pathway activity — BLOOD_Lymphoma

Explore this box plot interactively →