Opsonization

Across TCGA cell cohorts, RNA activity of the Opsonization pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are METTL23, SLC24A1, and NUDT11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, METTL23 grouped by Opsonization-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	METTL23 →	+0.806	+1.518	.002	<.001	3	5
OVARY	SLC24A1 →	-1.000	-0.908	.003	.005	3	4
SKIN	NUDT11 →	+1.166	+0.966	.004	.004	3	4
PANCREAS	SLC8A1 →	+0.972	+1.085	.002	<.001	3	4
BLOOD_Leukemia	TXNDC15 →	+0.645	+1.077	.009	.008	3	4
BLOOD_Lymphoma	GNA13 →	+2.370	+1.929	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

METTL23 by Opsonization activity — LIVER

Explore this box plot interactively →