Regulation of blood pressure

Across TCGA cell cohorts, RNA activity of the Regulation of blood pressure pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSK3A, GADD45G, and HAAO, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GSK3A grouped by Regulation of blood pressure-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GSK3A →	-0.211	-0.674	<.001	.005	3	4
CNS	GADD45G →	-0.201	-0.875	.001	.005	3	4
CNS	HAAO →	-0.235	-1.230	<.001	<.001	3	4
CNS	OR2H1 →	-0.438	-1.080	<.001	<.001	3	4
URINARY_TRACT	BDH1 →	-0.359	-0.173	.005	.005	2	5
LARGE_INTESTINE	TLX3 →	-0.127	-0.516	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSK3A by Regulation of blood pressure activity — OVARY

Explore this box plot interactively →