Estrogen metabolic process

Across TCGA cell cohorts, RNA activity of the Estrogen metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MLPH, PDZK1, and ZNF317, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MLPH grouped by Estrogen metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MLPH →	-2.649	-0.917	.001	<.001	3	4
BREAST	PDZK1 →	-2.508	-0.833	.002	.001	3	4
LUNG_NSCLC_LUSC	ZNF317 →	+0.595	+1.317	.003	.002	3	4
OESOPHAGUS	FLVCR2 →	-0.983	-1.089	.002	.002	2	4
PANCREAS	STRA6 →	-3.045	-1.372	.003	<.001	3	3
STOMACH	ATP5F1B →	+0.932	+1.153	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MLPH by Estrogen metabolic process activity — BREAST

Explore this box plot interactively →